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Drugs com npp beetroot Beetroot Uses Benefits Dosage Drugs com Herbal Database Clinical Overview Botany History Chemistry Uses and Pharmacology Dosing Pregnancy Lactation Adverse Reactions Toxicology Use Despite traditional use of beetroot for antitumor carminative emmenagogue and hemostatic properties clinical trials are lacking to substantiate these claims Data suggest a role as an antioxidant as a natural source of nitrates and nitrites and a potential use in exercise performance or cardiovascular conditions although evidence is limited In the food industry beetroot is used for its color Dosing Limited data are available to support therapeutic dosing Contraindications Although not contraindicated excessive consumption is not advised in patients with hemochromatosis or Wilson disease because of the potential for iron and copper accumulation See full list on www drugs com B vulgaris is an herbaceous biennial growing 1 to 2 m in height It bears heart shaped leaves measuring up to 40 cm long in cultivated varieties The 5 petaled flowers are 3 to 5 mm in diameter green or reddish tinged and densely arranged along a long inflorescence A hard cluster of nutlets are formed as fruits The main root of the beetroot plant is swollen and composed of alternating layers of darker and lighter conductive and storage tissues Chevallier 1996 PLANTS 2008Synonyms include Beta altissima and Beta brasiliensis See full list on www drugs com References to beetroot are found in Roman scripts for treating fever and constipation and for use as an aphrodisiac Hippocrates is said to have advocated using beet leaves for binding wounds The plant was used throughout the Middle Ages for a variety of ailments The term nature 39 s candy has been associated with the historical use of sugar from beet in the Napoleonic Wars Traditional use includes antitumor carminative emmenagogue and hemostatic properties Chevallier 1996 Fugh Berman 2004 Beetroot juice is utilized in the food industry as an alternative to synthetic colorants in jams jellies and sauces Lee 2005 Stintzing 2004 See full list on www drugs com The leaves contain varying amounts of calcium phosphorous iron vitamins A and C niacin thiamine and riboflavin Fugh Berman 2004 A ribosome inactivating protein beetin has been identified in mature plant leaves Iglesias 2005 The roots mostly consist of saccharose and the same elements and vitamins found in the leaves as well as folate zinc and magnesium The color is mainly derived from water soluble nitrogenous pigments called betalains betacyanins red or betaxanthins yellow including betanin betanidin betalmic acid and vulgaxanthin Blázovics 2007 Frank 2005 Lee 2005 Ninfali 2007 Heat labile phenolic acids and flavonol glycosides have also been described Lee 2005 Ninfali 2007 Assays of the chemical constituents have been performed by high performance liquid chromatography and spectrophotometry Kanner 2001 Pavlov 2005 See full list on www drugs com Recent discovery of the nitrate nitrite nitric oxide NO pathway has led to a better understanding of enterally ingested nitrate from beetroot After systemic absorption second pass metabolism takes place when nitrate is concentrated and secreted from the salivary glands Nitrate reductases produced by the oral microbiome convert nitrate to nitrite in the mouth which is then further converted at the tissue level to NO A process that may be limited or prevented with the routine use of antibacterial mouthwashes Files 2020 Other oral hygiene or practices that have also been noted as possibly altering the oral microbiome and affecting nitrate metabolism are teeth brushing with antiseptic toothpaste chewing gum consuming sweets taking stimulants such as caffeine or drinking alcohol Lopez Samanes 2020 See full list on www drugs com Beetroot juice is often used in trials because greater benefit from plant based nitrate ingestion has been observed compared to sodium nitrate supplementation Nyakayiru 2017 Limited data are available to support therapeutic dosing 500 mL of beetroot juice has been administered as a single dose in healthy volunteers and is estimated to contain approximately 360 mg of betanin Kanner 2001 Webb 2008 A range of 140 to 250 mL beetroot juice over 7 days to 4 weeks has been used in trials with nitrate dosing that ranged from 5 1 to 45 mmol day Nyakayiru 2017 Siervo 2013 See full list on www drugs com Information regarding safety and efficacy in pregnancy and lactation is lacking Beetroot has been used traditionally as an emmenagogue and in the treatment of fibroids but clinical trial data are lacking Cattle fed large amounts of sugar beet leaves showed infertility and genital tract abnormalities mice showed increases in uterine weight Isoflavones are reported to have been detected in the seeds of certain sugar beet varieties Fugh Berman 2004 See full list on www drugs com Cross sensitivity to sticky weed Parietaria and beet has been recorded Váli 2007 Beeturia red urine after eating beetroot is found in approximately 15 of the populationStintzing 2004 and coloration of the blood has also been documented with no apparent consequence Minciullo 2007 See full list on www drugs com Data are limited Accumulation of metals copper iron magnesium manganese phosphorus and zinc in the liver with excess consumption is possible and was demonstrated in rats Caution is warranted in patients with hemochromatosis or Wilson disease Blázovics 2007 See full list on www drugs com

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